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Clnktm1Vei
Targeted Allele Detail
Nomenclature
Symbol: Clnktm1Vei
Name: cytokine-dependent hematopoietic cell linker; targeted mutation 1, Andre Veillette
MGI ID: MGI:3050561
Synonyms: Clnk-
Gene: Clnk  Location: Chr5:38706462-38876812 bp, - strand  Genetic Position: Chr5, 20.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91590
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 5, the first exon common to all alternatively spliced transcripts, was disrupted by the insertion of a neo. Southern blot confirmed recombination and no wild-type or truncated transcripts were shown in Northern blot. Western blotting further confirmed lack of protein, truncated or full-length. (J:91590)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clnk Mutation:  14 strains or lines available
References
Original:  J:91590 Utting O, et al., Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Mol Cell Biol. 2004 Jul;24(13):6067-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory