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Park2tm1Tmd
Targeted Allele Detail
Nomenclature
Symbol: Park2tm1Tmd
Name: Parkinson disease (autosomal recessive, juvenile) 2, parkin; targeted mutation 1, Ted M Dawson
MGI ID: MGI:3050230
Gene: Park2  Location: Chr17:10840384-12063361 bp, + strand  Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
Decrease in tyrosine hydroxylase (TH) containing neurons in the locus coeruleus (LC) of Park2tm1Tmd/Park2tm1Tmd mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91487
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Park2 Mutation:  14 strains or lines available
References
Original:  J:91487 Von Coelln R, et al., Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10744-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory