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Targeted Allele Detail
Symbol: Nlrc4tm1Vmd
Name: NLR family, CARD domain containing 4; targeted mutation 1, Vishva M Dixit
MGI ID: MGI:3046934
Synonyms: Ipaf-, N4KO, NLRC4-
Gene: Nlrc4  Location: Chr17:74733254-74766140 bp, - strand  Genetic Position: Chr17, 45.64 cM
Germline Transmission:  Earliest citation of germline transmission: J:91292
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NCrl
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe sequence encoding amino acids 8-374 was replaced with a PGK-neo cassette. Western blot indicated absence of transcript in mutant macrophages. (J:91292)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nlrc4 Mutation:  46 strains or lines available
Original:  J:91292 Mariathasan S, et al., Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature. 2004 Jul 8;430(6996):213-8
All:  103 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory