Fezf2^tm1Hibi
Targeted Allele Detail

Summary

• Symbol: Fezf2^tm1Hibi
• Name: Fez family zinc finger 2; targeted mutation 1, Masahiko Hibi
• MGI ID: MGI:3046867
• Synonyms: Fezl^-
• Gene: Fezf2 Location: Chr14:10121574-10127669 bp, + strand Genetic Position: Chr14, 6.36 cM
• Alliance: Fezf2^tm1Hibi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91247
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing translation stop codons, the promotorless beta-galactosidase gene, and MC1 promoter-linked neo resistance gene replaced most of the coding region (amino acids 27-455). Southern blot and PCR confirmed recombination, however, heterozygous embryos did not express beta-galactosidase activity. (J:91247)

Expression

In Mice Carrying this Mutation:	41 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fezf2 Mutation: 49 strains or lines available

References

• Original: J:91247 Hirata T, et al., Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons. Dev Dyn. 2004 Jul;230(3):546-56
• All: 17 reference(s)