Phenotypes associated with this allele

• Allele Symbol: Fezf2^tm1Hibi
• Allele Name: targeted mutation 1, Masahiko Hibi
• Allele ID: MGI:3046867
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fezf2^tm1Hibi/Fezf2^tm1Hibi	involves: 129S1/Sv * 129X1/SvJ	MGI:5767285
hm2	Fezf2^tm1Hibi/Fezf2^tm1Hibi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3046917
cx3	Fezf1^tm1Hibi/Fezf1^tm1Hibi Fezf2^tm1Hibi/Fezf2^+	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3767819
cx4	Fezf1^tm1Hibi/Fezf1^tm1Hibi Fezf2^tm1Hibi/Fezf2^tm1Hibi	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3767818

Genotype
MGI:5767285

hm1

• Allelic Composition: Fezf2^tm1Hibi/Fezf2^tm1Hibi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon guidance ( J:214959 )

• at P7, mice show the axonal guidance phenotype observed in mice that are homozygous for Ephb1^tm1Dgen and heterozygous for Fezf2^tm1Skm

• mice also show loss of axonal projections to the cerebral peduncle and the spinal cord

increased anterior commissure size ( J:214959 )

• enlarged anterior commissure at P7

cellular

abnormal axon guidance ( J:214959 )

• at P7, mice show the axonal guidance phenotype observed in mice that are homozygous for Ephb1^tm1Dgen and heterozygous for Fezf2^tm1Skm

• mice also show loss of axonal projections to the cerebral peduncle and the spinal cord

Genotype
MGI:3046917

hm2

• Allelic Composition: Fezf2^tm1Hibi/Fezf2^tm1Hibi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

premature death ( J:91247 )

• on a solid diet, died around 4 weeks of age

• survived when given a liquid diet

behavior/neurological

abnormal food preference ( J:91247 )

• did not eat solid food after weaning

• would continue on a liquid diet

abnormal stationary movement ( J:91247 )

• twitchy movements

hyperactivity ( J:91247 )

• moved 10X more often than normals

growth/size/body

postnatal growth retardation ( J:91247 )

• growth reduction after weaning to a solid diet

• growth normal while nursing

nervous system

abnormal telencephalon development ( J:91247 )

• boundary between cortical plate and intermediate zone irregular in lateral cortex

• reduced size of intermediate zone and fimbria/fornix

• subplate neurons failed to attract thalamocortical axons

abnormal thalamus morphology ( J:91247 )

• region containing thalamocortical axons smaller at E17.5

• reduced numbers of thalamocortical axons reaching the cortex

• some thalamocortical axons project of aberrant locations

Genotype
MGI:3767819

cx3

• Allelic Composition: Fezf1^tm1Hibi/Fezf1^tm1Hibi; Fezf2^tm1Hibi/Fezf2⁺
• Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

abnormal dentate gyrus morphology ( J:119561 )

• at E17.5

small olfactory bulb ( J:119561 )

• at E15.5

Genotype
MGI:3767818

cx4

• Allelic Composition: Fezf1^tm1Hibi/Fezf1^tm1Hibi; Fezf2^tm1Hibi/Fezf2^tm1Hibi
• Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

abnormal diencephalon morphology ( J:119561 )

• at E18.5, the habenulo-intepeduncular tracts are small and abnormally located and the mammilothalamic tract is absent

• however, pretectum development is normal

• at E12.5, the prethalamus is absent and the caudal diencephalon is expanded

• at E10.5, regionalization of the diencephalons is defective

small thalamus ( J:119561 )

• the prethalamus is absent and the thalamus is reduced in size

abnormal hippocampus CA3 region morphology ( J:119561 )

• the CA3 region is strongly reduced

absent dentate gyrus ( J:119561 )

• the dentate gyrus is absent

abnormal neocortex morphology ( J:119561 )

• formation of the neocortex is impaired

small olfactory bulb ( J:119561 )

• the olfactory bulb is nearly completely lost