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Fmn1tm1.1Zlr
Targeted Allele Detail
Nomenclature
Symbol: Fmn1tm1.1Zlr
Name: formin 1; targeted mutation 1.1, Rolf Zeller
MGI ID: MGI:3046837
Synonyms: Fmndelta10.24
Gene: Fmn1  Location: Chr2:113327736-113716767 bp, + strand  Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91385
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated from Fmn1tm1Zlr by crossing to Tg(CMV-cre)1Cgn mice. Cre expression causes the excision of 170 kb containing the remaining exons between 10 and 24. The protein product is identical to that of Fmn1tm1Zlr and, in addition, transcription of Grem1 is disrupted. (J:91385)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmn1 Mutation:  6 strains or lines available
Notes
Homozygous mutant mice display limb deformities and a low frequency of renal abnormalities, but not renal agenesis or aberrant lung patterning phenotypes. This mutation is a hypomorphic allele, allelic to Grem1tm1Azun. Compound heterozygous mutant mice show a fully penetrant "limb deformity" limb phenotype, but not the phenotypes causing neonatal lethality. Transcription was not detected in the limb bud mesenchyme of compound heterozygous mutant embryos (J:91385).
References
Original:  J:91385 Zuniga A, et al., Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 2004 Jul 1;18(13):1553-64
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory