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Fmn1tm1Zlr
Targeted Allele Detail
Nomenclature
Symbol: Fmn1tm1Zlr
Name: formin 1; targeted mutation1, Rolf Zeller
MGI ID: MGI:3046836
Synonyms: Fmndelta10
Gene: Fmn1  Location: Chr2:113327771-113709855 bp, + strand  Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91385
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 10 was completely replaced with a PGK-Neomycin expression cassette and a loxP site was inserted further downstream in intron 10. A correctly targeted ES cell line was further modified by the insertion of a floxed PGK-Hygro cassette and an En-2 splice acceptor-IRES-LacZ expression cassette into exon 24. Removal of exon 10 causes a frame shift mutation, which disrupts the highly conserved formin homology domain SH2 and results in a protein product truncated at the exon 9/10 boundary. (J:91385)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmn1 Mutation:  33 strains or lines available
References
Original:  J:91385 Zuniga A, et al., Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 2004 Jul 1;18(13):1553-64
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory