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Mfge8tm1Osa
Targeted Allele Detail
Nomenclature
Symbol: Mfge8tm1Osa
Name: milk fat globule-EGF factor 8 protein; targeted mutation 1, Shigekazu Nagata
MGI ID: MGI:3044898
Synonyms: MFG-E8-
Gene: Mfge8  Location: Chr7:79133768-79149060 bp, - strand  Genetic Position: Chr7, 44.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90633
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomysin resistance cassette replaced exons 4-6. Southern blot confirmed recombination in mutant tails. Western blot analysis showed no protein expression in macrophages. (J:90633)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mfge8 Mutation:  14 strains or lines available
References
Original:  J:90633 Hanayama R, et al., Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science. 2004 May 21;304(5674):1147-50
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory