Kras^tm4.1Tyj
Targeted Allele Detail

Summary

• Symbol: Kras^tm4.1Tyj
• Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4.1, Tyler Jacks
• MGI ID: MGI:3044565
• Synonyms: Lox-K-ras^G12D
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^tm4.1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89333
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The loxP site flanked STOP cassette upstream of the inserted oncogenic Kras2 sequence was removed in the male germline via Cre-mediated recombination where cre expression was driven by a protamine promoter. (J:89333)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 76 strains or lines available

References

• Original: J:89333 Tuveson DA, et al., Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004 Apr;5(4):375-87
• All: 2 reference(s)