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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krastm4.1Tyj
targeted mutation 4.1, Tyler Jacks
MGI:3044565
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Krastm4.1Tyj/Kras+ Not Specified MGI:3044566
cn2
 		Krastm4.1Tyj/Kras+
Spry2tm1Mrt/Spry2tm1Mrt 		involves: 129P2/OlaHsd MGI:3716395


Genotype
MGI:3044566
ht1
Allelic
Composition		 Krastm4.1Tyj/Kras+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4.1Tyj mutation (0 available); any Kras mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:89333 )
• no viable embryos are found after E11.5

cardiovascular system
enlarged heart ( J:89333 )
• at E9.5 mutant embryos display cardiomegaly

embryo
decreased embryo size ( J:89333 )
• mutant embryos are small
abnormal embryonic neuroepithelium morphology ( J:89333 )
• neuroepithelial sections have extensive areas of architectural distortion and apoptosis

growth/size/body
enlarged heart ( J:89333 )
• at E9.5 mutant embryos display cardiomegaly
decreased embryo size ( J:89333 )
• mutant embryos are small

nervous system
increased embryonic neuroepithelium apoptosis ( J:89333 )
• neuroepithelial sections have extensive areas of apoptosis
abnormal embryonic neuroepithelium morphology ( J:89333 )
• neuroepithelial sections have extensive areas of architectural distortion and apoptosis
abnormal brain development ( J:89333 )
• at E9.5 mutant embryos display abnormal brain development

integument
pallor ( J:89333 )
• mutant embryos are pale

cellular
increased embryonic neuroepithelium apoptosis ( J:89333 )
• neuroepithelial sections have extensive areas of apoptosis




Genotype
MGI:3716395
cn2
Allelic
Composition		 Krastm4.1Tyj/Kras+
Spry2tm1Mrt/Spry2tm1Mrt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4.1Tyj mutation (0 available); any Kras mutation (69 available)
Spry2tm1Mrt mutation (1 available); any Spry2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:119477 )
• number of induced tumors and total tumor area are significantly higher with Spry2 deficiency following treatment with adenoviral Cre

respiratory system
increased lung tumor incidence ( J:119477 )
• number of induced tumors and total tumor area are significantly higher with Spry2 deficiency following treatment with adenoviral Cre




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory