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Nr4a2tm1Omc
Targeted Allele Detail
Nomenclature
Symbol: Nr4a2tm1Omc
Name: nuclear receptor subfamily 4, group A, member 2; targeted mutation 1, Orla M Conneely
MGI ID: MGI:3043985
Synonyms: Nurr1-
Gene: Nr4a2  Location: Chr2:57106830-57124003 bp, - strand  Genetic Position: Chr2, 31.66 cM
Loss of Ptx3 expression and increased cell death in ventral midbrain region of newborn Nr4a2tm1Omc/Nr4a2tm1Omc mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46856
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neo cassette was inserted into exon 3, downstream of the start codon and upstream of the DNA-binding domain. (J:46856)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr4a2 Mutation:  24 strains or lines available
References
Original:  J:46856 Saucedo-Cardenas O, et al., Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4013-8
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory