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Epha5tm1Jgf
Targeted Allele Detail
Nomenclature
Symbol: Epha5tm1Jgf
Name: Eph receptor A5; targeted mutation 1, John G Flanagan
MGI ID: MGI:3043641
Synonyms: Epha5lacZ
Gene: Epha5  Location: Chr5:84054761-84417382 bp, - strand  Genetic Position: Chr5, 43.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90078
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe endogenous gene was disrupted by the insertion of a cassette containing lacZ and PGK-neo. Beta galactosidase activity was detected in mutant mice indicating the production of a fusion protein predicted to consist of the extracellular, transmembrane, and juxtamembrane domains followed by beta-galactosidase. The protein putatively lacks the entire tyrosine kinase and C-terminal domains, but the kinase-independent functions are expetcted to remain intact. (J:90078)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 673 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epha5 Mutation:  34 strains or lines available
References
Original:  J:90078 Feldheim DA, et al., Loss-of-function analysis of EphA receptors in retinotectal mapping. J Neurosci. 2004 Mar 10;24(10):2542-50
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory