Retn^tm1Laz
Targeted Allele Detail

Summary

• Symbol: Retn^tm1Laz
• Name: resistin; targeted mutation 1, Mitchell A Lazar
• MGI ID: MGI:3043419
• Synonyms: rstn-
• Gene: Retn Location: Chr8:3705770-3709818 bp, + strand Genetic Position: Chr8, 1.92 cM, cytoband A1
• Alliance: Retn^tm1Laz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90033
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 - 4 were replaced with LacZ and a nuclear localization signal via homologous recombination. Protein and mRNA expression were absent from white adipose tissue. Immunoblot analysis and radioimmunoassay also confirmed the absence of dirculating protein. LacZ expression is detected in white adipose tissue. (J:90033)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Retn Mutation: 14 strains or lines available

References

• Original: J:90033 Banerjee RR, et al., Regulation of fasted blood glucose by resistin. Science. 2004 Feb 20;303(5661):1195-8
• All: 12 reference(s)