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Nrxn2tm1Sud
Targeted Allele Detail
Nomenclature
Symbol: Nrxn2tm1Sud
Name: neurexin II; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:3042719
Gene: Nrxn2  Location: Chr19:6418738-6533217 bp, + strand  Genetic Position: Chr19, 4.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89452
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Immunoblotting of mutant brain confirmed lack of protein expression. This knock-out affects the alpha isoform specifically. The beta isoform, transcribed from a downstream promoter, is not affected.. (J:89452)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nrxn2 Mutation:  16 strains or lines available
References
Original:  J:89452 Missler M, et al., Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 2003 Jun 26;423(6943):939-48
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory