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Ntrk2tm1Rohr
Targeted Allele Detail
Nomenclature
Symbol: Ntrk2tm1Rohr
Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Baerbel Rohrer
MGI ID: MGI:3039928
Synonyms: trkB-, trkBneo
Gene: Ntrk2  Location: Chr13:58806596-59133970 bp, + strand  Genetic Position: Chr13, 31.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89227
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first coding exon, exon S, was replaced with a neo cassette by homologous recombination. Exon S, which encodes 31 codons for the signal peptide and the start codon, is common to both kinase and nonkinase isoforms. While Northern blot of homozygous mutants showed a small amount of aberrant transcript, Western blotting demonstrated that no receptors were detected in the homozygous mutant mice brains. (J:88782)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntrk2 Mutation:  38 strains or lines available
References
Original:  J:89227 Rohrer B, et al., Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. J Neurosci. 1999 Oct 15;19(20):8919-30
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory