Phenotypes associated with this allele

• Allele Symbol: Ntrk2^tm1Rohr
• Allele Name: targeted mutation 1, Baerbel Rohrer
• Allele ID: MGI:3039928
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk2^tm1Rohr/Ntrk2^tm1Rohr	involves: ICR	MGI:3040879
hm2	Ntrk2^tm1Rohr/Ntrk2^tm1Rohr	Not Specified	MGI:3040875
ht3	Ntrk2^tm1Rohr/Ntrk2^+	Not Specified	MGI:3040877

Genotype
MGI:3040879

hm1

• Allelic Composition: Ntrk2^tm1Rohr/Ntrk2^tm1Rohr
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:89227 )

• most die within 48 hours of birth, although some survive to 3 weeks of age

growth/size/body

decreased body size ( J:89227 )

• small body size, reaching only 1/3 of the body weight of the controls

respiratory system

abnormal breathing pattern ( J:89227 )

• irregularly patterned breathing

vision/eye

abnormal pupillary reflex ( J:89227 )

• mutants display a pupillarly light reflex but with a very slow response time

decreased amacrine cell number ( J:89227 )

• the number of AII amacrine cells is slightly, but significantly, reduced in the retina

abnormal retina rod cell outer segment morphology ( J:89227 )

• rod outer segment dimensions and rhodopsin content in P16 mutants are comparable to those of controls at P12, indicating that outer segement development is slowed

abnormal retina development ( J:89227 )

• rod migration and differentiation proceed at slower rates than in wild-type controls

abnormal eyelid morphology ( J:89227 )

• eyelids separate but do not open entirely

abnormal rod electrophysiology ( J:89227 )

• the gain and kinetics of the rod phototransduction signal in dark-adapted P16 mice is similar to those of P12 control mice, indicating a delay of about 4 days in the maturation of the transduction function

• lack of b-wave at P12, indicating failed signal transmission in the retinal rod pathway

abnormal vision ( J:89227 )

• mutants show no visually guided orientation behavior and do not turn away from a visual cliff

nervous system

decreased amacrine cell number ( J:89227 )

• the number of AII amacrine cells is slightly, but significantly, reduced in the retina

abnormal retina rod cell outer segment morphology ( J:89227 )

• rod outer segment dimensions and rhodopsin content in P16 mutants are comparable to those of controls at P12, indicating that outer segement development is slowed

behavior/neurological

impaired righting response ( J:89227 )

• mutants have problems righting themselves

abnormal pupillary reflex ( J:89227 )

• mutants display a pupillarly light reflex but with a very slow response time

Genotype
MGI:3040875

hm2

• Allelic Composition: Ntrk2^tm1Rohr/Ntrk2^tm1Rohr
• Genetic Background: Not Specified

mortality/aging

postnatal lethality, complete penetrance ( J:119332 )

• mice die within 3 weeks of birth

reproductive system

impaired granulosa cell differentiation ( J:88782 )

♀ • total number of granulosa cells per ovary is reduced by 23%

decreased granulosa cell proliferation ( J:88782 )

♀ • attenuated granulosa cell proliferation

decreased secondary ovarian follicle number ( J:88782 )

♀ • number of secondary follicles is reduced

impaired ovarian folliculogenesis ( J:88782 )

♀ • follicular growth is arrested at the primary 3b stage

growth/size/body

decreased body weight ( J:119332 )

• mice only reach 45% of wild-type weight

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:88782 )

• levels are reduced by about 25%

endocrine/exocrine glands

impaired granulosa cell differentiation ( J:88782 )

♀ • total number of granulosa cells per ovary is reduced by 23%

decreased granulosa cell proliferation ( J:88782 )

♀ • attenuated granulosa cell proliferation

decreased secondary ovarian follicle number ( J:88782 )

♀ • number of secondary follicles is reduced

impaired ovarian folliculogenesis ( J:88782 )

♀ • follicular growth is arrested at the primary 3b stage

nervous system

abnormal optic nerve morphology ( J:119332 )

• optic nerve at P14 contains approximately 70% fewer myelinated axons

vision/eye

abnormal optic nerve morphology ( J:119332 )

• optic nerve at P14 contains approximately 70% fewer myelinated axons

cellular

impaired granulosa cell differentiation ( J:88782 )

♀ • total number of granulosa cells per ovary is reduced by 23%

decreased granulosa cell proliferation ( J:88782 )

♀ • attenuated granulosa cell proliferation

Genotype
MGI:3040877

ht3

• Allelic Composition: Ntrk2^tm1Rohr/Ntrk2⁺
• Genetic Background: Not Specified

homeostasis/metabolism

abnormal circulating corticosterone level ( J:179918 )

• abnormal rebound of corticosterone levels following dexamethasone

decreased circulating corticosterone level ( J:179918 )

• evening levels are decreased

• levels are raised by stress but lower compared to controls 1 h after stress

decreased circulating follicle stimulating hormone level ( J:88782 )

• levels are reduced by about 25%

decreased circulating adrenocorticotropin level ( J:179918 )

• evening levels are decreased