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Transgene Detail
Symbol: Tg(Th-MYCN)41Waw
Name: transgene insertion 41, William A Weiss
MGI ID: MGI:3039395
Synonyms: MYCN, Th-MYCN, TH-NMYC
Transgene: Tg(Th-MYCN)41Waw  Location: unknown  
Histology and immunohistochemistry of neuroblastoma Tg(Th-MYCN)41Waw/0 tumors

Show the 4 phenotype image(s) involving this allele.

Strain of Origin:  BALB/c and C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Th-MYCN)41Waw expresses 1 gene
Mutation detailsThe rat tyrosine hydrolase promoter directs expression of human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN) to migrating cells of the neural crest during early development. Expression was found in the adrenal gland with marginal expression in brain, heart, testes and spleen. (J:41126)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Mice carrying this transgene on a 129X1/SvJ background are predisposed to neuroblastoma and show many of the features of the human childhood disease. Genomic analysis of tumors from these mice have shown allelic imbalance in chromosomal regions orthologous to those found in human neuroblastoma.
Original:  J:41126 Weiss WA, et al., Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 1997 Jun 2;16(11):2985-95
All:  43 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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