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Tg(Th-MYCN)41Waw
Transgene Detail
Nomenclature
Symbol: Tg(Th-MYCN)41Waw
Name: transgene insertion 41, William A Weiss
MGI ID: MGI:3039395
Synonyms: MYCN, Th-MYCN, TH-NMYC
Transgene: Tg(Th-MYCN)41Waw  Location: unknown  
Transgene
origin
Strain of Origin:  BALB/c and C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Mice carrying this transgene on a 129X1/SvJ background are predisposed to neuroblastoma and show many of the features of the human childhood disease. Genomic analysis of tumors from these mice have shown allelic imbalance in chromosomal regions orthologous to those found in human neuroblastoma.
Phenotypic Similarity to Human Syndrome: neuroblastoma

References
Original:  J:41126 Weiss WA, et al., Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 1997 Jun 2;16(11):2985-95
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory