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Idd5.2C57BL/10SnJ
QTL Variant Detail
Nomenclature
QTL variant: Idd5.2C57BL/10SnJ
Name: insulin dependent diabetes susceptibility 5.2; C57BL/10SnJ
MGI ID: MGI:3036879
Synonyms: Idd5.2
QTL: Idd5.2  Location: unknown  Genetic Position: Chr1, Syntenic
Variant
origin
Strain of Specimen:  C57BL/10SnJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. (J:88667)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Candidate Genes

J:107559

Congenic mouse strains within the Idd5.2 (MGI: Idd5b) region of mouse Chromosome 1 were utilized to suggest that solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (Slc11a1) is a likely candidate for Idd5.2. Using RNAi (RNA interference) the authors showed that a knockdown of Slc11a1 (allele Nramp1) had a detectable effect on diabetes incidence conferred within the Idd5.2 region.

References
Original:  J:88667 Hill NJ, et al., NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes. 2000 Oct;49(10):1744-7
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory