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Targeted Allele Detail
Symbol: Ifngtm1Yiw
Name: interferon gamma; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:3036127
Synonyms: GKO, IFN-gamma-, IFNgammaKO
Gene: Ifng  Location: Chr10:118441047-118445892 bp, + strand  Genetic Position: Chr10, 66.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:41632
Parent Cell Line:  A3-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ gene followed by a neomycin resistance gene replaced exon 1 starting at the initiation codon through part of intron 1. Northern blot analysis failed to detect mRNA in appropriately stimulated spleen cells and protein product could not be detected immunologically. (J:41632)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ifng Mutation:  27 strains or lines available
Original:  J:41632 Tagawa Y, et al., Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. J Immunol. 1997 Aug 1;159(3):1418-28
All:  46 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory