About   Help   FAQ
Ifngtm1Yiw
Targeted Allele Detail
Nomenclature
Symbol: Ifngtm1Yiw
Name: interferon gamma; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:3036127
Synonyms: GKO, IFN-gamma-, IFNgammaKO
Gene: Ifng  Location: Chr10:118441047-118445892 bp, + strand  Genetic Position: Chr10, 66.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41632
Parent Cell Line:  A3-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ gene followed by a neomycin resistance gene replaced exon 1 starting at the initiation codon through part of intron 1. Northern blot analysis failed to detect mRNA in appropriately stimulated spleen cells and protein product could not be detected immunologically. (J:41632)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ifng Mutation:  27 strains or lines available
References
Original:  J:41632 Tagawa Y, et al., Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. J Immunol. 1997 Aug 1;159(3):1418-28
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory