About   Help   FAQ
Pgrtm1Lyd
Targeted Allele Detail
Summary
Symbol: Pgrtm1Lyd
Name: progesterone receptor; targeted mutation 1, John P Lydon
MGI ID: MGI:3032652
Synonyms: PRKOlacZ, PRlacZ
Gene: Pgr  Location: Chr9:8899834-8968612 bp, + strand  Genetic Position: Chr9, 2.46 cM
Alliance: Pgrtm1Lyd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79968
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ gene was inserted in frame within exon 1 followed by a PGK-neomycin resistance gene. This replaced sequence from 356bp to 724bp downsteam of the initiator codon for the "B" isoform. As a result, the coding sequence for a 122aa fragment was removed including the initiation codon for the "A" isoform. Care was taken not to disrupt the estrogen response elements. (J:79968)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:  73 strains or lines available
References
Original:  J:79968 Ismail PM, et al., A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Mol Endocrinol. 2002 Nov;16(11):2475-89
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory