Phenotypes associated with this allele

• Allele Symbol: Pgr^tm1Lyd
• Allele Name: targeted mutation 1, John P Lydon
• Allele ID: MGI:3032652
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgr^tm1Lyd/Pgr^tm1Lyd	involves: 129S7/SvEvBrd	MGI:3789045
hm2	Pgr^tm1Lyd/Pgr^tm1Lyd	involves: 129S7/SvEvBrd * C57BL/6	MGI:3032665
ht3	Pgr^tm1Lyd/Pgr^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3032666

Genotype
MGI:3789045

hm1

• Allelic Composition: Pgr^tm1Lyd/Pgr^tm1Lyd
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:130208 )

• following treatment with dydrogesterone, uterine support cells exhibit an increase in TH1 to TH2 cytokine ratio compared to wild-type mice

Genotype
MGI:3032665

hm2

• Allelic Composition: Pgr^tm1Lyd/Pgr^tm1Lyd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

behavior/neurological

abnormal sexual interaction ( J:79968 )

♀ • females did not exhibit sexual behavior

endocrine/exocrine glands

abnormal mammary gland development ( J:79968 )

♀ • abnormal mammary development

absent corpus luteum ( J:79968 )

♀

reproductive system

abnormal female reproductive system morphology ( J:79968 )

♀

absent corpus luteum ( J:79968 )

♀

uterus hyperplasia ( J:79968 )

♀

abnormal reproductive system physiology ( J:79968 )

abnormal ovulation ( J:79968 )

♀ • ovulation could not be stimulated with exogenous hormones

female infertility ( J:79968 )

♀

integument

abnormal mammary gland development ( J:79968 )

♀ • abnormal mammary development

Genotype
MGI:3032666

ht3

• Allelic Composition: Pgr^tm1Lyd/Pgr⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:79968 )

• heterozygous mice are phenocopies of wild-type mice