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Tg(Pdx1-cre)6Tuv
Transgene Detail
Nomenclature
Symbol: Tg(Pdx1-cre)6Tuv
Name: transgene insertion 6, David A Tuveson
MGI ID: MGI:3032531
Synonyms: Pdx1-cre, PDX-1-Cre, Pdx1-CreTuv, Tg(Ipf1-cre)1Tuv, Tg(Ipf1-cre)6Tuv
Transgene: Tg(Pdx1-cre)6Tuv  Location: unknown  Genetic Position: Chr8, Syntenic
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Tg(Pdx1-cre)6Tuv/? pancreata display extensive loss of exocrine tissue

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe transgenic construct is composed of a Cre recombinase coding sequence under the control of the Pdx1 promoter. Cre expression is thus directed to islet cells of the pancreas. Line 6 was inserted into chromosome 8 about 48 kb upstream of Zfp423 (chr8:90,531,639; NCBI37/mm9) with elements of human ACTB 3'UTR and polyA signal, and a 1.5 kb genomic duplication at the integration site. (J:87973, J:240920)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdx1     Summary of all recombinase alleles driven by Pdx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 23 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:87973 Hingorani SR, et al., Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec;4(6):437-50
All:  241 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory