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Spontaneous Allele Detail
Symbol: Acadsdel-J
Name: acyl-Coenzyme A dehydrogenase, short chain; deletion, Jackson
MGI ID: MGI:3029768
Synonyms: Bcd-1c, Scad
Gene: Acads  Location: Chr5:115110299-115119346 bp, - strand  Genetic Position: Chr5, 55.99 cM
Strain of Origin:  BALB/cByJ
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
Mutation detailsA 278bp deletion occurs which starts in intron "A" and includes exon "B" and the first 78bp of exon "C". As a result of this deletion, mRNA transcription is reduced to about 35% of normal and includes two forms, a longer normal length transcript and a shorter misspliced form. If these mRNAs were translated they both would result in truncated products. Protein product is undetectable immunologically and there is a total absence of enzyme activity. (J:12776, J:50729)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Acads Mutation:  5 strains or lines available
Original:  J:14707 Wood PA, et al., Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. Pediatr Res. 1989 Jan;25(1):38-43
All:  18 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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