Stat3^tm1Dnl
Targeted Allele Detail

Summary

• Symbol: Stat3^tm1Dnl
• Name: signal transducer and activator of transcription 3; targeted mutation 1, James E Darnell
• MGI ID: MGI:3028651
• Synonyms: SA, Stat3 S727A, STAT3SA-
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm1Dnl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87599
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: In order to ablate serine phosphorylation at codon 727, a serine to alanine substitution mutation was introduced into exon 23 at codon 727 via homologous recombination. A floxed neo cassette inserted downstream of the polyadenylation signal was excised via cre-mediated recombination. (J:87599)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 70 strains or lines available

References

• Original: J:87599 Shen Y, et al., Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation. Mol Cell Biol. 2004 Jan;24(1):407-19
• All: 10 reference(s)