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Fgf3tm1Sng
Targeted Allele Detail
Summary
Symbol: Fgf3tm1Sng
Name: fibroblast growth factor 3; targeted mutation 1, Thomas Schimmang
MGI ID: MGI:3027990
Synonyms: Fgf3-
Gene: Fgf3  Location: Chr7:144392349-144397085 bp, + strand  Genetic Position: Chr7, 88.85 cM
Alliance: Fgf3tm1Sng page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87221
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1b, 2, and 3 were replaced by a loxP site, an Fgf3 cDNA and a floxed neomycin resistance gene. Heterozygous mice were then mated to deleter-cre mice to remove the cDNA and neomycin insert. Absence of transcripts was confirmed by RNA in situ hybridization. (J:87221)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf3 Mutation:  16 strains or lines available
References
Original:  J:87221 Alvarez Y, et al., Requirements for FGF3 and FGF10 during inner ear formation. Development. 2003 Dec;130(25):6329-38
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory