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Fgf3tm1Sng
Targeted Allele Detail
Nomenclature
Symbol: Fgf3tm1Sng
Name: fibroblast growth factor 3; targeted mutation 1, Thomas Schimmang
MGI ID: MGI:3027990
Synonyms: Fgf3-
Gene: Fgf3  Location: Chr7:144838083-144844436 bp, + strand  Genetic Position: Chr7, 88.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87221
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1b, 2, and 3 were replaced by a loxP site, an Fgf3 cDNA and a floxed neomycin resistance gene. Heterozygous mice were then mated to deleter-cre mice to remove the cDNA and neomycin insert. Absence of transcripts was confirmed by RNA in situ hybridization. (J:87221)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf3 Mutation:  5 strains or lines available
References
Original:  J:87221 Alvarez Y, et al., Requirements for FGF3 and FGF10 during inner ear formation. Development. 2003 Dec;130(25):6329-38
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory