Phenotypes associated with this allele

• Allele Symbol: Fgf3^tm1Sng
• Allele Name: targeted mutation 1, Thomas Schimmang
• Allele ID: MGI:3027990
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf3^tm1Sng/Fgf3^tm1Sng	involves: 129P2/OlaHsd * C57BL/6	MGI:3027997
cx2	Fgf3^tm1Sng/Fgf3^tm1Sng Fgf10^tm1Ska/Fgf10^tm1Ska	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3027998

Genotype
MGI:3027997

hm1

• Allelic Composition: Fgf3^tm1Sng/Fgf3^tm1Sng
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:87221 )

N • homozygotes are completely viable

behavior/neurological

behavior/neurological phenotype ( J:87221 )

N • no abnormal behavior was observed

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:87221 )

N • adults with normal Peyer's reflex and no obvious abnormalities in cochlea or vestibular system

small otic vesicle ( J:87221 )

• otic vesicle somewhat small at E10.75 but otherwise normal

limbs/digits/tail

abnormal tail morphology ( J:87221 )

• abnormal tail structure first seen at E11

• curved tail

short tail ( J:87221 )

thick tail ( J:87221 )

reproductive system

reproductive system phenotype ( J:87221 )

N • homozygotes are fertile

Genotype
MGI:3027998

cx2

• Allelic Composition: Fgf3^tm1Sng/Fgf3^tm1Sng; Fgf10^tm1Ska/Fgf10^tm1Ska
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:87221 )

• no double homozygous embryos found after E10

hearing/vestibular/ear

abnormal ear development ( J:87221 )

• severe loss of otic tissue by E8-E10

small otic vesicle ( J:87221 )

• reduced size of otic vesicles and more ventrally located by E9-E10

• extent of effect on otic vesicle was variable

nervous system

absent vestibulocochlear ganglion ( J:87221 )