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Vnn1tm1Pna
Targeted Allele Detail
Nomenclature
Symbol: Vnn1tm1Pna
Name: vanin 1; targeted mutation 1, Philippe Naquet
MGI ID: MGI:3027932
Synonyms: V1-, Vanin-1 -
Gene: Vnn1  Location: Chr10:23894688-23905343 bp, + strand  Genetic Position: Chr10, 11.33 cM, cytoband A1-B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65449
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a PGK neomycin cassette in reverse orientation. Northern blot analysis of mRNA from kidney and RT-PCR confirmed the absence of transcript while Western blot analysis and immunohistochemistry demonstrated the absence of protein. (J:65449)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Vnn1 Mutation:  21 strains or lines available
Notes
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References
Original:  J:65449 Pitari G, et al., Pantetheinase activity of membrane-bound vanin-1: lack of free cysteamine in tissues of vanin-1 deficient mice. FEBS Lett. 2000 Oct 20;483(2-3):149-54
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory