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Targeted Allele Detail
Symbol: Spo11tm1Rdco
Name: SPO11 meiotic protein covalently bound to DSB; targeted mutation 1, R Daniel Camerini-Otero
MGI ID: MGI:3027823
Synonyms: Spo11-
Gene: Spo11  Location: Chr2:172977700-172993576 bp, + strand  Genetic Position: Chr2, 95.64 cM, cytoband H4
Germline Transmission:  Earliest citation of germline transmission: J:65881
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 starting after the sequence coding for the 3rd amino acid after the second "in frame" ATG through nucleotide 35 of the first intron was replaced with a PGK-neomycin cassette in reverse orientation. This removes the splice donor site. Absence of transcript was confirmed by Northern blot analysis. (J:65881)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spo11 Mutation:  6 strains or lines available
Original:  J:65881 Romanienko PJ, et al., The mouse spo11 gene is required for meiotic chromosome synapsis. Mol Cell. 2000 Nov;6(5):975-87
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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