Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11tm1Rdco mutation
(0 available);
any
Spo11 mutation
(20 available)
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reproductive system
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• meiosis arrested at zygotene stage
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cellular
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• meiosis arrested at zygotene stage
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11tm1Rdco mutation
(0 available);
any
Spo11 mutation
(20 available)
|
|
|
reproductive system
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• defects seen in fetal ovaries at E15
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• problems in early stages of meiosis I
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• male germ cells lack double strand breaks and are defective recombination and synapsis
• preleptotene pairing is impaired
• transgene expression of Spo11alpha does not rescue preleptotene pairing
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• meiosis in spermatocytes normal through leptotene stage
• meiosis arrested at zygotene stage
• little or no synapsis (about 5-10% of nuclei)
• synapsis that does occur is between nonhomologous chromosomes
• lack of Rad51 and Dmc1 foci
• no spermatocytes reach pachytene stage
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• many tubules are barren
• about 20% of tubules with clusters of apoptotic cells
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endocrine/exocrine glands
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• defects seen in fetal ovaries at E15
|
|
• many tubules are barren
• about 20% of tubules with clusters of apoptotic cells
|
cellular
|
• problems in early stages of meiosis I
|
|
• male germ cells lack double strand breaks and are defective recombination and synapsis
• preleptotene pairing is impaired
• transgene expression of Spo11alpha does not rescue preleptotene pairing
|
|
• meiosis in spermatocytes normal through leptotene stage
• meiosis arrested at zygotene stage
• little or no synapsis (about 5-10% of nuclei)
• synapsis that does occur is between nonhomologous chromosomes
• lack of Rad51 and Dmc1 foci
• no spermatocytes reach pachytene stage
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maeltm1Bort mutation
(0 available);
any
Mael mutation
(24 available)
Spo11tm1Rdco mutation
(0 available);
any
Spo11 mutation
(20 available)
|
|
|
reproductive system
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• large numbers of double stranded DNA breaks occur in spermatocytes
|
cellular
|
• large numbers of double stranded DNA breaks occur in spermatocytes
|