About   Help   FAQ
Cdkn2atm4Rdp
Targeted Allele Detail
Nomenclature
Symbol: Cdkn2atm4Rdp
Name: cyclin-dependent kinase inhibitor 2A; targeted mutation 4, Ronald DePinho
MGI ID: MGI:2687203
Synonyms: Ink4a/ARFF2-3, Ink4a/Arflox, Ink4a/Arf Lox, Ink4a-p19ARF-
Gene: Cdkn2a  Location: Chr4:89274471-89294653 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87196
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  25 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Soft Tissue Sarcoma J:125101 in double Kras and Cdkn2a mutants.

References
Original:  J:87196 Aguirre AJ, et al., Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 2003 Dec 15;17(24):3112-26
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory