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Tg(Fabp1-Ccnd1)4Rdb
Transgene Detail
Nomenclature
Symbol: Tg(Fabp1-Ccnd1)4Rdb
Name: transgene insertion 4, R Daniel Beauchamp
MGI ID: MGI:2684226
Transgene: Tg(Fabp1-Ccnd1)4Rdb  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Fabp1-Ccnd1)4Rdb expresses 1 gene
 
Mutation detailsThis transgenic construct contains the mouse cyclin D1 gene driven by the rat fatty acid binding protein promoter. Transgenic mice overexpress cyclin D1 in the liver and epithelial cells of the small intestine and colon. A lower level of expression occurs in the kidneys. This line carries 20-fold more transgene copies than the F2 line, which itself carries multiple transgene copies. (J:70394)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:70394 Deane NG, et al., Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res. 2001 Jul 15;61(14):5389-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory