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Targeted Allele Detail
Symbol: Catsper2tm1Gar
Name: cation channel, sperm associated 2; targeted mutation 1, David L Garbers
MGI ID: MGI:2683843
Synonyms: CatSper2-
Gene: Catsper2  Location: Chr2:121392631-121413792 bp, - strand  Genetic Position: Chr2, 60.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:86972
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment encompassing exons 2 through 5. The deleted region included the start codon and encoded the first three transmembrane helices. Protein was undetected in homozygous mutant mice by Western blot and immunocytochemical analyses of spermatozoa. (J:86972)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Catsper2 Mutation:  11 strains or lines available
Original:  J:86972 Quill TA, et al., Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14869-74
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory