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Prdx6tm1Abf
Targeted Allele Detail
Nomenclature
Symbol: Prdx6tm1Abf
Name: peroxiredoxin 6; targeted mutation 1, Aron B Fisher
MGI ID: MGI:2683326
Synonyms: 1-cysPrx -
Gene: Prdx6  Location: Chr1:161240112-161251210 bp, - strand  Genetic Position: Chr1, 69.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86750
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of intron 2 and the first part of exon 3 were replaced by a neomycin resistance gene in the reverse orientation. Lack of gene product in homozygotes was demonstrated by both real-time PCR and Western blot analysis. (J:86750)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prdx6 Mutation:  30 strains or lines available
References
Original:  J:86750 Mo Y, et al., 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. FEBS Lett. 2003 Dec 4;555(2):192-8
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory