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Zap70m1Saka
Spontaneous Allele Detail
Nomenclature
Symbol: Zap70m1Saka
Name: zeta-chain (TCR) associated protein kinase; mutation 1, Shimon Sakaguchi
MGI ID: MGI:2683318
Synonyms: SKG, ZAP-70skg, ZAP-70W163C
Gene: Zap70  Location: Chr1:36761798-36782818 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Mutation
origin
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA G-to-T transversion at nucleotide 489, resulting in a tryptophan to cysteine substitution at codon 163 (W163C), was identified on a BALB/c genetic background. (J:86607)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:  15 strains or lines available
References
Original:  J:86607 Sakaguchi N, et al., Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 2003 Nov 27;426(6965):454-60
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory