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Tg(Ins2-CD80)3B7Flv
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-CD80)3B7Flv
Name: transgene insertion 3B7, Richard Flavell
MGI ID: MGI:2682826
Synonyms: RIP-B7, RIP-B7-1, RIP-B7.1, RIP-CD80
Transgene: Tg(Ins2-CD80)3B7Flv  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA/Ca)F2
Transgene
description
Transgene Type:    Transgenic (random, expressed)
Mutation:    Insertion
    The transgene contains a human CD80 antigen gene driven by the rat insulin II promoter (Ins2). (J:88250)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Notes
Mice carrying this transgene that also are homozygous for Prkdcscid are characterized by pancreatic beta cells that express a rat insulin II promoter regulated transgene encoding the human CD80 T cell co-stimulatory molecule.

References
Original:  J:88250 Guerder S, et al., Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5138-42
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory