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Krt2Dsk2
Chemically induced Allele Detail
Nomenclature
Symbol: Krt2Dsk2
Name: keratin 2; dark skin 2
MGI ID: MGI:2682236
Gene: Krt2  Location: Chr15:101810689-101818169 bp, - strand  Genetic Position: Chr15, 57.03 cM
Mutation
origin
Strain of Origin:  C3HeB/J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThe mutation was identified as an A to C transversion causing a missense mutation that predicts a Thr5000Pro substitution in the rod 2b domain, a domain known to be important for keratin keratin interactions. (J:81301)
Inheritance:    Dominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt2 Mutation:  5 strains or lines available
References
Original:  J:81301 Fitch KR, et al., Genetics of dark skin in mice. Genes Dev. 2003 Jan 15;17(2):214-28
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory