About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krt2Mhdadsk2
Martin Hrabe de Angelis dark skin 2
MGI:2682236
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Krt2Mhdadsk2/Krt2Mhdadsk2 involves: C3HeB/FeJ * C57BL/6J MGI:2682251
ht2
 		Krt2Mhdadsk2/Krt2+ C3HeB/FeJ-Krt2Mhdadsk2/Ieg MGI:2682252


Genotype
MGI:2682251
hm1
Allelic
Composition		 Krt2Mhdadsk2/Krt2Mhdadsk2
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt2Mhdadsk2 mutation (0 available); any Krt2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

hearing/vestibular/ear
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

limbs/digits/tail
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

craniofacial
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

integument
thick epidermis ( J:81301 )
• histologically determined in the foot pads and tail at one month of age
scaly skin ( J:81301 )
• affecting ear skin, tail and footpads
• scaling is evident by 3-4 weeks of age
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

growth/size/body
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
bullous congenital ichthyosiform erythroderma DOID:0060877 OMIM:146800
 J:81301




Genotype
MGI:2682252
ht2
Allelic
Composition		 Krt2Mhdadsk2/Krt2+
Genetic
Background		 C3HeB/FeJ-Krt2Mhdadsk2/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt2Mhdadsk2 mutation (0 available); any Krt2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

hearing/vestibular/ear
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

limbs/digits/tail
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

craniofacial
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

integument
thick epidermis ( J:81301 )
• histologically determined in the foot pads and tail at one month of age
scaly skin ( J:81301 )
• affecting ear skin, tail and footpads
• scaling is evident by 3-4 weeks of age
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident by 6-12 weeks of age
increased tail pigmentation ( J:81301 )
• dark pigmentation of the tail evident by 6-12 weeks of age

growth/size/body
increased ear pigmentation ( J:81301 )
• dark pigmentation of the ears evident by 6-12 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
bullous congenital ichthyosiform erythroderma DOID:0060877 OMIM:146800
 J:81301




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory