S1pr1^tm2Rlp
Targeted Allele Detail

Summary

• Symbol: S1pr1^tm2Rlp
• Name: sphingosine-1-phosphate receptor 1; targeted mutation 2, Richard L Proia
• MGI ID: MGI:2681911
• Synonyms: S1P1^loxP, S1Pr1^fl, S1pr1^flox
• Gene: S1pr1 Location: Chr3:115504082-115508704 bp, - strand Genetic Position: Chr3, 50.0 cM
• Alliance: S1pr1^tm2Rlp page

Discontinuous smooth muscle cell coverage around the aorta in S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/? mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86450
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites, one upstream in the intron and two more downstream on both sides of an inserted neomycin selection cassette. These gene modifications did not disrupt the locus. (J:86450)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any S1pr1 Mutation: 30 strains or lines available

References

• Original: J:86450 Allende ML, et al., G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003 Nov 15;102(10):3665-7
• All: 48 reference(s)