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S1pr1tm2Rlp
Targeted Allele Detail
Nomenclature
Symbol: S1pr1tm2Rlp
Name: sphingosine-1-phosphate receptor 1; targeted mutation 2, Richard L Proia
MGI ID: MGI:2681911
Synonyms: S1P1loxP, S1Pr1fl, S1pr1flox
Gene: S1pr1  Location: Chr3:115504082-115508704 bp, - strand  Genetic Position: Chr3, 50.0 cM
Discontinuous smooth muscle cell coverage around the aorta in S1pr1tm1Rlp/S1pr1tm2Rlp Tg(Tek-cre)1Ywa/? mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86450
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2 was flanked by loxP sites, one upstream in the intron and two more downstream on both sides of an inserted neomycin selection cassette. These gene modifications did not disrupt the locus. (J:86450)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any S1pr1 Mutation:  20 strains or lines available
References
Original:  J:86450 Allende ML, et al., G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003 Nov 15;102(10):3665-7
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory