Gria2^tm1Sans
Targeted Allele Detail

Summary

• Symbol: Gria2^tm1Sans
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1, Nathalie Sans
• MGI ID: MGI:2680703
• Synonyms: GluR-, GluR2^-
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm1Sans page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86218
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 11 and flanking intronic sequence was replaced with a single loxP site after cre-mediated excision in vitro. Neither normal transcript nor protein were detected in homozygous mutant mice by RNase protection and Western blot analysis. (J:86218)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 75 strains or lines available

References

• Original: J:86218 Sans N, et al., Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit. J Neurosci. 2003 Oct 15;23(28):9367-73
• All: 3 reference(s)