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Targeted Allele Detail
Symbol: Nod2tm1Pmu
Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Peter J Murray
MGI ID: MGI:2680581
Synonyms: Card15-, Nod2-
Gene: Nod2  Location: Chr8:88647315-88688474 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:86264
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe start codon, first CARD domain and half of the second CARD domain were eliminated by replacing the first exon with a PGK-neomycin resistance gene. RT-PCR on macrophage extracts demonstrated the absence of gene transcript. (J:86264)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:  6 strains or lines available
Original:  J:86264 Pauleau AL, et al., Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol. 2003 Nov;23(21):7531-9
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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