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Targeted Allele Detail
Symbol: Crebbptm1Reck
Name: CREB binding protein; targeted mutation 1, Richard Eckner
MGI ID: MGI:2679376
Synonyms: cbpAS
Gene: Crebbp  Location: Chr16:4081334-4213957 bp, - strand  Genetic Position: Chr16, 2.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:85950
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Dominant negative, Null/knockout)
Mutation:    Nucleotide substitutions
Mutation detailsAcetyltransferase (AT) activity was ablated via the incorporation of engineered point mutations at the endogenous locus. The mutations substitute alanine and serine for tryptophan and tyrosine (WY(1503-1504)AS). A single loxP site remained in the intron preceding the missense mutations after the excision of floxed neo cassette used for selection. Western blot analysis indicated mutant protein was expressed at wild-type levels. (J:85950)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crebbp Mutation:  18 strains or lines available
Original:  J:85950 Roth JF, et al., Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 2003 Oct 1;22(19):5186-96
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory