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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crebbptm1Reck
targeted mutation 1, Richard Eckner
MGI:2679376
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Crebbptm1Reck/Crebbp+ involves: 129P2/OlaHsd MGI:2679423


Genotype
MGI:2679423
ht1
Allelic
Composition		 Crebbptm1Reck/Crebbp+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Reck mutation (0 available); any Crebbp mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:85949 )
• about 10% of embryos die between E12.5 and E15.5
postnatal lethality, complete penetrance ( J:85950 )
• neonates do not survive beyond 1 or 2 days following birth
embryonic lethality during organogenesis, incomplete penetrance ( J:85949 )
• about 10% of embryos die between E12.5 and E15.5

cardiovascular system
thin ventricle myocardium compact layer ( J:85949 )
• compact layer of the ventricles is moderately thinner than in wild-type
abnormal heart development ( J:85949 )
• less severe than in Ep300tm1Reck heterozygotes

muscle
muscle phenotype ( J:85950 )
N
• mutants appear to have normal myogenesis
thin ventricle myocardium compact layer ( J:85949 )
• compact layer of the ventricles is moderately thinner than in wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory