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Ikbkbtm1.1Cgn
Targeted Allele Detail
Nomenclature
Symbol: Ikbkbtm1.1Cgn
Name: inhibitor of kappaB kinase beta; targeted mutation 1.1, University of Cologne
MGI ID: MGI:2678816
Synonyms: IkkDeltaKD
Gene: Ikbkb  Location: Chr8:22659212-22706589 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79132
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe loxP flanked region including exon 7 was excised from Ikbkbtm1Cgn via cre mediated recombination. The deleted region encoded amino acids 160 through 189, including serines 177 and 181, two residues of the activation loop that are essential for kinase activity. Excision of the floxed fragment results in splicing between exons 6 and 8, producing a protein that lacks kinase activity but that is incorporated into the Ikbk complex. (J:85810)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  9 strains or lines available
References
Original:  J:79132 Pasparakis M, et al., IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med. 2002 Sep 16;196(6):743-52
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory