Tas1r3^tm1Rfm
Targeted Allele Detail

Summary

• Symbol: Tas1r3^tm1Rfm
• Name: taste receptor, type 1, member 3; targeted mutation 1, Robert F Margolskee
• MGI ID: MGI:2678581
• Synonyms: T1r3^-
• Gene: Tas1r3 Location: Chr4:155943725-155947810 bp, - strand Genetic Position: Chr4, 87.65 cM
• Alliance: Tas1r3^tm1Rfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85822
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence fragment encompassing all six exons was replaced with a floxed neo cassette inserted by homologous recombination. Protein was undetected by indirect immunofluorescence of homozygous mutant circumvallate papillae. (J:85822)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tas1r3 Mutation: 36 strains or lines available

References

• Original: J:85822 Damak S, et al., Detection of sweet and umami taste in the absence of taste receptor T1r3. Science. 2003 Aug 8;301(5634):850-3
• All: 22 reference(s)