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Targeted Allele Detail
Symbol: Ntrk1tm1Apat
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Ardem Patapoutian
MGI ID: MGI:2678328
Synonyms: Ntrk1-, TkrAtaulacZ, TrkALacZ, TrkA(tauLacZ)*tm1Lfr
Gene: Ntrk1  Location: Chr3:87685551-87702469 bp, - strand  Genetic Position: Chr3, 38.62 cM
Germline Transmission:  Earliest citation of germline transmission: J:92099
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector containing tau-lacZ, SV40 polyA and floxed neo was inserted immediately downstream of the ATG in exon 1. Crossing with Actb-cre mice excised the floxed neo. Southern blot confirmed recombination. X-gal staining indicated expression of lacZ in dorsal root ganglia and skin in heterozygotes. (J:92099)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  37 strains or lines available
Original:  J:92099 Moqrich A, et al., Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci. 2004 Aug;7(8):812-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory