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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ntrk1tm1Apat
targeted mutation 1, Ardem Patapoutian
MGI:2678328
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ntrk1tm1Apat/Ntrk1tm1Apat involves: 129S1/Sv MGI:3052172
cx2
 		Baxtm1Sjk/Baxtm1Sjk
Ntrk1tm1Apat/Ntrk1tm1Apat 		involves: 129S1/Sv * 129X1/SvJ MGI:4413457


Genotype
MGI:3052172
hm1
Allelic
Composition		 Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk1tm1Apat mutation (1 available); any Ntrk1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased sensory neuron number ( J:92099 )
• a 70 - 90% reduction in sensory neuron number is seen




Genotype
MGI:4413457
cx2
Allelic
Composition		 Baxtm1Sjk/Baxtm1Sjk
Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Ntrk1tm1Apat mutation (1 available); any Ntrk1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:154926 )
• E14.5, extension of hind limb nerves is defective compared to in wild-type mice
• extension of the lateral plantar nerve is reduced 9% compared to in wild-type mice
• at E15.5, the number and order of branches in the medial digital branch of the lateral plantar nerve in the fifth digit are impaired compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory