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Targeted Allele Detail
Symbol: Crhr1tm2Wrst
Name: corticotropin releasing hormone receptor 1; targeted mutation 2, Wolfgang Wurst
MGI ID: MGI:2678096
Synonyms: CRF-R1loxP, Crhr1lox
Gene: Crhr1  Location: Chr11:104132855-104175523 bp, + strand  Genetic Position: Chr11, 67.77 cM
Germline Transmission:  Earliest citation of germline transmission: J:85745
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 9 through 13 were flanked by a 5' single loxP site and 3' single loxP site followed by a splice acceptor, lacZ, and neo. The floxed sequence encodes transmembrane regions 4 through 7, the G-protein coupling domain, and the intracellular cytoplasmic tail. (J:85745)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crhr1 Mutation:  20 strains or lines available
Original:  J:85745 Muller MB, et al., Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci. 2003 Oct;6(10):1100-7
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory