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Hif1atm1.1Stom
Targeted Allele Detail
Nomenclature
Symbol: Hif1atm1.1Stom
Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 1.1, Shuhei Tomita
MGI ID: MGI:2677899
Synonyms: Hif-1alphadelta
Gene: Hif1a  Location: Chr12:73901375-73947530 bp, + strand  Genetic Position: Chr12, 31.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85763
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 13, 14, and 15 were deleted by cre-mediated recombination of flanking loxP sites. The deleted region encoded the C-terminal transactivation domain that is involved in response to hypoxia, Cri2 recruitment, and efficient nuclear localization. Though a truncated protein consisting was detected, it was reported to be non-functional. (J:85763)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hif1a Mutation:  12 strains or lines available
References
Original:  J:85763 Tomita S, et al., Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol. 2003 Oct;23(19):6739-49
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory