Phenotypes associated with this allele

• Allele Symbol: Hif1a^tm1.1Stom
• Allele Name: targeted mutation 1.1, Shuhei Tomita
• Allele ID: MGI:2677899
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hif1a^tm1.1Stom/Hif1a^tm1.1Stom	Not Specified	MGI:3815313
cn2	Hif1a^tm1Stom/Hif1a^tm1.1Stom Tg(Nes-cre)1Kag/0	Not Specified	MGI:3815314

Genotype
MGI:3815313

hm1

• Allelic Composition: Hif1a^tm1.1Stom/Hif1a^tm1.1Stom
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:85763 )

• embryonic lethality reported

Genotype
MGI:3815314

cn2

• Allelic Composition: Hif1a^tm1Stom/Hif1a^tm1.1Stom; Tg(Nes-cre)1Kag/0
• Genetic Background: Not Specified

nervous system

abnormal cortical plate morphology ( J:85763 )

• density of blood vessels is reduced

hydrocephaly ( J:85763 )

• in adults

enlarged lateral ventricles ( J:85763 )

• in adults

abnormal cerebral hemisphere morphology ( J:85763 )

abnormal cerebral cortex morphology ( J:85763 )

• thinner than in controls at E19

• dense nuclei found with a wavy architecture

• apoptotic neural and glial cells detected

• atrophy of the cerebral cortex in adults

loss of cortex neurons ( J:85763 )

• significant reduction of neurons at 10 weeks of age although six layered structure of the cortex is maintained

abnormal occipital lobe morphology ( J:85763 )

• 36% reduction of neurons at 10 weeks of age

abnormal temporal lobe morphology ( J:85763 )

• 36% loss of neurons in the perirhinal cortex at 10 weeks of age

loss of hippocampal neurons ( J:85763 )

• 12% reduction of neurons on the dorsal side

behavior/neurological

behavior/neurological phenotype ( J:85763 )

N • spontaneous activity is normal

abnormal spatial learning ( J:85763 )

• significantly impaired memory consolidation after 4 days of testing using a radial maze task