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Tg(ACTB-cre)1Tes
Transgene Detail
Nomenclature
Symbol: Tg(ACTB-cre)1Tes
Name: transgene insertion 1, Lino Tessarollo
MGI ID: MGI:2677702
Transgene: Tg(ACTB-cre)1Tes  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe sequence encoding cre recombinase was under the control of the human beta-actin promoter. This line differs from other beta-actin driven transgenes in that expression was driven during early embryogenesis in a stochastic manner. While uniform transgenic expression was detected in the testis, mosaic patterns of cre-mediated recombination were observed in various organs including the liver, heart, lung, pancreas, brain, retina, spleen, and adrenal gland. (J:85513)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: ACTB     Summary of all recombinase alleles driven by ACTB.
 

Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:85513 Ma W, et al., Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res. 2003 Sep 1;63(17):5320-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory